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The Lancet Commission on Transforming Primary Health Care in the Post-COVID-19 Era Lancet (IF 98.4) Pub Date : 2025-02-10 William Chi-Wai Wong, Vivian Lin, Xiaoxuan Fang, Michael Kidd
No Abstract
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Targeted radiation adds precision to cancer therapy Nat. Med. (IF 58.7) Pub Date : 2025-02-11
Radionuclide therapies can target and treat several cancer types, spurring growing interest from pharma.
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Phospho-tau serine-262 and serine-356 as biomarkers of pre-tangle soluble tau assemblies in Alzheimer’s disease Nat. Med. (IF 58.7) Pub Date : 2025-02-10 Tohidul Islam, Emily Hill, Eric E. Abrahamson, Stijn Servaes, Denis S. Smirnov, Xuemei Zeng, Anuradha Sehrawat, Yijun Chen, Przemys?aw R. Kac, Hlin Kvartsberg, Maria Olsson, Emma Sjons, Fernando Gonzalez-Ortiz, Joseph Therriault, Cécile Tissot, Ivana Del Popolo, Nesrine Rahmouni, Abbie Richardson, Victoria Mitchell, Henrik Zetterberg, Tharick A. Pascoal, Tammaryn Lashley, Mark J. Wall, Douglas Galasko
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A potent epigenetic editor targeting human PCSK9 for durable reduction of low-density lipoprotein cholesterol levels Nat. Med. (IF 58.7) Pub Date : 2025-02-10 Frederic Tremblay, Qiang Xiong, Shrijal S. Shah, Chih-Wei Ko, Kenneth Kelly, Mary S. Morrison, Cristiana Giancarlo, Ricardo N. Ramirez, Erica M. Hildebrand, Sarah B. Voytek, Gabriel K. El Sebae, Shane H. Wright, Liam Lofgren, Scott Clarkson, Christine Waters, Samantha J. Linder, Songlei Liu, Taesun Eom, Shefal Parikh, Yuki Weber, Salette Martinez, Padma Malyala, Sahar Abubucker, Ari E. Friedland, Morgan
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Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia Nat. Med. (IF 58.7) Pub Date : 2025-02-10 Jorge J. Llibre-Guerra, M. Victoria Fernandez, Nelly Joseph-Mathurin, Shijia Bian, Kathleen Carter, Yan Li, Andrew J. Aschenbrenner, Cyril Pottier, Wendy Sigurdson, Eric McDade, Brian A. Gordon, Alan E. Renton, Tammie L. S. Benzinger, Laura Iba?ez, Nico Barthelemy, Matthew Johnson, Jason Hassenstab, Guoqiao Wang, Alison M. Goate, Dan Western, Ciyang Wang, Diana Hobbs, Alisha Daniels, Celeste Karch
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Artificial intelligence for direct-to-physician reporting of ambulatory electrocardiography Nat. Med. (IF 58.7) Pub Date : 2025-02-10 L. S. Johnson, P. Zadrozniak, G. Jasina, A. Grotek-Cuprjak, J. G. Andrade, E. Svennberg, S. Z. Diederichsen, W. F. McIntyre, S. Stavrakis, J. Benezet-Mazuecos, P. Krisai, Z. Iakobishvili, A. Laish-Farkash, S. Bhavnani, E. Ljungstr?m, J. Bacevicius, N. L. van Vreeswijk, M. Rienstra, R. Spittler, J. A. Marx, A. Oraii, A. Miracle Blanco, A. Lozano, I. Mustafina, S. Zafeiropoulos, R. Bennett, J. Bisson
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US aid cuts are an opportunity to reimagine global health Nat. Med. (IF 58.7) Pub Date : 2025-02-10
The global south should become self-reliant by investing in health.
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Race and Ethnicity in Biomedical Research JAMA (IF 63.1) Pub Date : 2025-02-10 Neil R. Powe, Ruqaiijah Yearby, M. Roy Wilson
This Viewpoint discusses recommendations to rethink and redesign the use of race and ethnicity in biomedical research and provides steps to facilitate the process.
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Evaluation of a Clinical Decision Support System for Imaging Requests JAMA (IF 63.1) Pub Date : 2025-02-10 Stijntje W. Dijk, Claudia Wollny, Joerg Barkhausen, Olav Jansen, Peter Mildenberger, Moritz C. Halfmann, Jonas Stroeder, Dimitris Rizopoulos, M. G. Myriam Hunink, Thomas Kroencke
ImportanceGiven the widespread use of medical imaging, evaluating the effectiveness of interventions to improve appropriateness is crucial for optimizing health care resources and patient outcomes.ObjectiveTo assess the effects of implementing a clinical decision support system (CDSS), the European Society of Radiology iGuide, on the appropriateness of the medical imaging ordering behavior of physicians
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Obecabtagene Autoleucel for B-Cell Acute Lymphoblastic Leukemia JAMA (IF 63.1) Pub Date : 2025-02-10 Najat Bouchkouj, Donna Przepiorka, Lola A. Fashoyin-Aje
This JAMA Insights discusses the recent FDA approval of obecabtagene autoleucel for adults with relapsed or refractory B-cell acute lymphoblastic leukemia and provides regulatory considerations.
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Contemporary Hormonal Contraception and Risk of Venous Thromboembolism JAMA (IF 63.1) Pub Date : 2025-02-10 Harman Gailan Hassan Yonis, Lina Steinrud M?rch, Ellen L?kkegaard, Kristian Kragholm, Amalie Lykkemark M?ller, Christian Torp-Pedersen, Amani Meaidi
This study assesses the risk of venous thromboembolism of different forms of hormonal contraception, including pills with estrogen and progestin, vaginal rings, patches, progestin-only pills, intrauterine devices, implants, and injections.
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Moving Toward Implementation of Responsible Artificial Intelligence in Health Care JAMA (IF 63.1) Pub Date : 2025-02-10 Michel E. van Genderen, Ilse M. J. Kant, Carlo Tacchetti, Stefan Jovinge
This Viewpoint discusses the Trustworthy and Responsible AI Network Europe (TRAIN-Europe) consortium, an effort of medical and AI experts to oversee, develop, and share ethical practices through collaboration and technological solutions designed to implement responsible AI practices.
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Launching the Trustworthy and Responsible AI Network (TRAIN) JAMA (IF 63.1) Pub Date : 2025-02-10 Peter J. Embí, David C. Rhew, Eric D. Peterson, Michael. J. Pencina
This Viewpoint lays out the genesis of Trustworthy and Responsible AI Network (TRAIN) and strategies for ensuring effective and safe use of AI throughout the US health care system.
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A new pathway for primary aldosteronism treatment Lancet (IF 98.4) Pub Date : 2025-02-07 Alexander A Leung, Gregory Kline
No Abstract
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Health-care system adaptability during wildfire disasters: crucial insights from LA County Lancet (IF 98.4) Pub Date : 2025-02-07 Attila J Hertelendy, Jeremy Maggin, Gregory R Ciottone
No Abstract
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Endoscopic, ultrasound-guided, radiofrequency ablation of aldosterone-producing adenomas (FABULAS): a UK, multicentre, prospective, proof-of-concept trial Lancet (IF 98.4) Pub Date : 2025-02-07 Giulia Argentesi, Xilin Wu, Alexander Ney, Emily Goodchild, Kate Laycock, Yun-Ni Lee, Russell Senanayake, James MacFarlane, Elisabeth Ng, Jessica Kearney, Sam O'Toole, Jackie Salsbury, Nick Carroll, Daniel Gillett, John A Tadross, Alison Marker, Edmund M Godfrey, George Goodchild, Jonathan P Bestwick, Mark Gurnell, Patrick Wilson
BackgroundUnilateral aldosterone-producing adrenal adenomas (APAs) are the potentially curable cause of 5% of all cases of hypertension. Their localisation (via adrenal vein sampling [AVS]) and removal (by laparoscopic adrenalectomy) require invasive procedures that are unattractive to patients. Molecular imaging-located, endoscopic ultrasound-guided trans-gastric radiofrequency ablation (EUS-RFA)
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Angola's cholera outbreak: a wake-up call for global action Lancet (IF 98.4) Pub Date : 2025-02-07 Mauer Alexandre da Ascens?o Gon?alves, Howard Lopes Ribeiro Júnior
No Abstract
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PEPFAR under review: what's at stake for PEPFAR's future Lancet (IF 98.4) Pub Date : 2025-02-07 Jirair Ratevosian, Gregorio Millett, Brian Honermann, Sara Bennett, Catherine Connor, Linda-Gail Bekker, Chris Beyrer
No Abstract
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Gender removal by fiat: impacts of new Trump administration edicts Lancet (IF 98.4) Pub Date : 2025-02-07 Nancy Krieger, Sofia Gruskin
No Abstract
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The Rise of Private Equity in Health Care - Not a Uniquely American Phenomenon. N. Engl. J. Med. (IF 96.2) Pub Date : 2025-02-08 Yashaswini Singh,Erin Fuse Brown,Irene Papanicolas
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The visible and hidden mortality caused by flooding Nat. Med. (IF 58.7) Pub Date : 2025-02-07 Andrew P. Morse
A study advances our understanding of how different flood events affect direct and indirect causes of mortality — providing useful insights for disaster response and preparedness.
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A new gut–brain therapeutic target for hepatic encephalopathy Nat. Med. (IF 58.7) Pub Date : 2025-02-07 Patricia P. Bloom
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Allogeneic approach unlocks CAR T cell benefits in solid tumors Nat. Med. (IF 58.7) Pub Date : 2025-02-07 Rozalyn Chok, Sneha Ramakrishna
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Confounding by familial factors influences the associations between maternal health and autism Nat. Med. (IF 58.7) Pub Date : 2025-02-07
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CAR-macrophage therapy for HER2-overexpressing advanced solid tumors: a phase 1 trial Nat. Med. (IF 58.7) Pub Date : 2025-02-07 Kim A. Reiss, Mathew G. Angelos, E. Claire Dees, Yuan Yuan, Naoto T. Ueno, Paula R. Pohlmann, Melissa L. Johnson, Joseph Chao, Olga Shestova, Jonathan S. Serody, Maggie Schmierer, Madison Kremp, Michael Ball, Rehman Qureshi, Benjamin H. Schott, Poonam Sonawane, Sabrina Ceeraz DeLong, Melissa Christiano, Ramona F. Swaby, Sascha Abramson, Ken Locke, Debora Barton, Eugene Kennedy, Saar Gill, Daniel Cushing
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Symptom monitoring with electronic patient-reported outcomes during cancer treatment: final results of the PRO-TECT cluster-randomized trial Nat. Med. (IF 58.7) Pub Date : 2025-02-07 Ethan Basch, Deborah Schrag, Jennifer Jansen, Sydney Henson, Brenda Ginos, Angela M. Stover, Philip Carr, Patricia A. Spears, Mattias Jonsson, Allison M. Deal, Antonia V. Bennett, Gita Thanarajasingam, Lauren Rogak, Bryce B. Reeve, Claire Snyder, Deborah Bruner, David Cella, Lisa A. Kottschade, Jane Perlmutter, Cindy Geoghegan, Barbara Given, Gina L. Mazza, Robert Miller, Jon F. Strasser, Dylan M.
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Telemedicine-supported lifestyle intervention for glycemic control in patients with CHD and T2DM: multicenter, randomized controlled trial Nat. Med. (IF 58.7) Pub Date : 2025-02-07 Stephan Mueller, Sophia M. T. Dinges, Felix Gass, Isabel Fegers-Wustrow, Julian Treitschke, Pia von Korn, Alessandra Boscheri, Janosch Krotz, Felix Freigang, Clara Dubois, Ephraim B. Winzer, Axel Linke, Frank Edelmann, Anna Feuerstein, Oliver Wolfram, Kerstin Sch?fer, Marlo Verket, Bernd Wolfarth, Marcus D?rr, Rolf Wachter, Bj?rn Hackenberg, Sarah Rust, Thomas Nebling, Volker Amelung, Martin Halle
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American chaos: standing up for health and medicine Lancet (IF 98.4) Pub Date : 2025-02-06
No Abstract
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On the quantification of military violence in Gaza Lancet (IF 98.4) Pub Date : 2025-02-06 James Smith, Duha Shellah, Zoé Samudzi
No Abstract
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Effect of normobaric hyperoxia in ischaemic stroke Lancet (IF 98.4) Pub Date : 2025-02-06 Diederik W J Dippel, Paula M Janssen
No Abstract
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Offline: Equality must be defended Lancet (IF 98.4) Pub Date : 2025-02-06 Richard Horton
No Abstract
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Trump agenda ignites legal challenges Lancet (IF 98.4) Pub Date : 2025-02-06 Susan Jaffe
No Abstract
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Health worker lay-offs in east Africa following US aid freeze Lancet (IF 98.4) Pub Date : 2025-02-06 Gilbert Nakweya
No Abstract
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Ukraine HIV services severely curtailed by US aid freeze Lancet (IF 98.4) Pub Date : 2025-02-06 Ed Holt
No Abstract
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Marcus Lacerda: aiming to eliminate vivax malaria Lancet (IF 98.4) Pub Date : 2025-02-06 Tony Kirby
No Abstract
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The rise of agentic AI teammates in medicine Lancet (IF 98.4) Pub Date : 2025-02-06 James Zou, Eric J Topol
No Abstract
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Health, rights, and work on the margins Lancet (IF 98.4) Pub Date : 2025-02-06 Sarah Boseley
No Abstract
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Faustine Ndugulile Lancet (IF 98.4) Pub Date : 2025-02-06 Andrew Green
Download: Download high-res image (274KB) Download: Download full-size image
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Attacks on reproductive rights in Brazil Lancet (IF 98.4) Pub Date : 2025-02-06 Carlos Abra?o Moura Valpassos, Stephania Gon?alves Klujsza, Jason Bartholomew Scott
No Abstract
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A health emergency: Afghanistan's nursing and midwifery ban Lancet (IF 98.4) Pub Date : 2025-02-06 Alaha Nasari, Sammer Marzouk, Najibullah Safi
No Abstract
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More physicians needed for more hope in South Korea Lancet (IF 98.4) Pub Date : 2025-02-06 Byung Uk Lee
No Abstract
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Comprehensive response to mpox in Pakistan Lancet (IF 98.4) Pub Date : 2025-02-06 Massab Umair, Muhammad Salman
No Abstract
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Unit 731 and history-informed professional identity formation Lancet (IF 98.4) Pub Date : 2025-02-06 Zohar Lederman, Lam Hin Lai Ivan, Cheuk Nam Liu, Aaron Hames, Jerry Menikoff
No Abstract
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Department of Error Lancet (IF 98.4) Pub Date : 2025-02-06
Kudo M, Ren Z, Guo Y, et al. Transarterial chemoembolisation combined with lenvatinib plus pembrolizumab versus dual placebo for unresectable, non-metastatic hepatocellular carcinoma (LEAP-012): a multicentre, randomised, double-blind, phase 3 study. Lancet 2025; 405: 203–15. The appendix of this Article has been corrected as of Feb 6, 2025.
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Department of Error Lancet (IF 98.4) Pub Date : 2025-02-06
St Peter SD, Noel-MacDonnell JR, Hall NJ, et al. Appendicectomy versus antibiotics for acute uncomplicated appendicitis in children: an open-label, international, multicentre, randomised, non-inferiority trial. Lancet 2025; 405: 233–40—In this Article, Prof Simon Eaton's affiliation should have been “UCL Great Ormond Street Institute of Child Health, London, UK”. This correction has been made to the
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Department of Error Lancet (IF 98.4) Pub Date : 2025-02-06
McCormack M, Eminowicz G, Gallardo D, et al. Induction chemotherapy followed by standard chemoradiotherapy versus standard chemoradiotherapy alone in patients with locally advanced cervical cancer (GCIG INTERLACE): an international, multicentre, randomised phase 3 trial. Lancet 2024; 404: 1525–35—The appendix of this Article has been corrected as of Feb 6, 2025.
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Department of Error Lancet (IF 98.4) Pub Date : 2025-02-06
Jamaluddine Z, Abukmail H, Aly S, Campbell OMR, Checchi F. Traumatic injury mortality in the Gaza Strip from Oct 7, 2023, to June 30, 2024: a capture–recapture analysis. Lancet 2025; 405: 469–77—The appendix of this Article has been corrected to fix labelling discrepancies. This correction has been made as of Feb 6, 2025.
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Normobaric hyperoxia combined with endovascular treatment for acute ischaemic stroke in China (OPENS-2 trial): a multicentre, randomised, single-blind, sham-controlled trial Lancet (IF 98.4) Pub Date : 2025-02-06 Weili Li, Jing Lan, Ming Wei, Lan Liu, Chengbei Hou, Zhifeng Qi, Chuanhui Li, Liqun Jiao, Qi Yang, Wenhuo Chen, Shuling Liu, Xincan Yue, Qinglin Dong, Haicheng Yuan, Zongen Gao, Xiangbin Wu, Changming Wen, Tong Li, Changchun Jiang, Di Li, Jing Zhou
BackgroundEndovascular treatment improves the recanalisation rate for patients with acute ischaemic stroke; however, even with endovascular treatment, approximately half of patients do not have a favourable functional outcome. We aimed to evaluate the effect of normobaric hyperoxia combined with endovascular treatment on functional outcomes up to 90 days after treatment in patients who had an acute
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Pregnancy and the liver Lancet (IF 98.4) Pub Date : 2025-02-06 Mussarat N Rahim, Catherine Williamson, Nikos A Kametas, Michael A Heneghan
Some of the physiological changes that occur in pregnancy manifest in the liver. These alterations might exacerbate or improve some pre-existent liver diseases, while many conditions remain unaffected. Some hepatic manifestations during pregnancy are secondary to disorders unique to pregnancy. Due to improved management of chronic conditions and assisted conception methods, pregnancies in people with
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Author Correction: Mutations in ACTRT1 and its enhancer RNA elements lead to aberrant activation of Hedgehog signaling in inherited and sporadic basal cell carcinomas Nat. Med. (IF 58.7) Pub Date : 2025-02-06 Elodie Bal, Hyun-Sook Park, Zakia Belaid-Choucair, Hülya Kayserili, Magali Naville, Marine Madrange, Elena Chiticariu, Smail Hadj-Rabia, Nicolas Cagnard, Francois Kuonen, Daniel Bachmann, Marcel Huber, Cindy Le Gall, Francine C?té, Sylvain Hanein, Rasim ?zgür Rosti, Ayca Dilruba Aslanger, Quinten Waisfisz, Christine Bodemer, Olivier Hermine, Fanny Morice-Picard, Bruno Labeille, Frédéric Caux, Juliette
Correction to: Nature Medicinehttps://doi.org/10.1038/nm.4368, published online 4 September 2017.
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Xenotransplantation of a Porcine Kidney for End-Stage Kidney Disease. N. Engl. J. Med. (IF 96.2) Pub Date : 2025-02-07 Tatsuo Kawai,Winfred W Williams,Nahel Elias,Jay A Fishman,Kerry Crisalli,Alban Longchamp,Ivy A Rosales,Michael Duggan,Shoko Kimura,Leela Morena,Thiago J Borges,Toshihide Tomosugi,Ahmad Karadagi,Tsukasa Nakamura,Kassem Safa,Alessia Giarraputo,Claire T Avillach,Eva D Patalas,R Neal Smith,David H Sachs,A Benedict Cosimi,Joren C Madsen,David K C Cooper,Richard Pierson,Steve Perrin,Ranjith P Anand,Sagar
Xenotransplantation offers a potential solution to the organ shortage crisis. A 62-year-old hemodialysis-dependent man with long-standing diabetes, advanced vasculopathy, and marked dialysis-access challenges received a gene-edited porcine kidney with 69 genomic edits, including deletion of three glycan antigens, inactivation of porcine endogenous retroviruses, and insertion of seven human transgenes
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Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis. N. Engl. J. Med. (IF 96.2) Pub Date : 2025-02-07 Richard A Furie,Brad H Rovin,Jay P Garg,Mittermayer B Santiago,Gustavo Aroca-Martínez,Adolfina Elizabeth Zuta Santillán,Damaris Alvarez,Cleyber Navarro Sandoval,Alexander M Lila,James A Tumlin,Amit Saxena,Fedra Irazoque Palazuelos,Harini Raghu,Bongin Yoo,Imran Hassan,Elsa Martins,Himanshi Sehgal,Petra Kirchner,Jorge Ross Terres,Theodore A Omachi,Thomas Schindler,William F Pendergraft,Ana Malvar,
BACKGROUND Obinutuzumab, a humanized type II anti-CD20 monoclonal antibody, provided significantly better renal responses than placebo in a phase 2 trial involving patients with lupus nephritis receiving standard therapy. METHODS In a phase 3, randomized, controlled trial, we assigned adults with biopsy-proven active lupus nephritis in a 1:1 ratio to receive obinutuzumab in one of two dose schedules
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Police consider manslaughter charges in 200 cases of harm and death at Brighton hospital. BMJ (IF 93.6) Pub Date : 2025-02-07 Clare Dyer
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Top Trumps: Who runs health in the new US government? BMJ (IF 93.6) Pub Date : 2025-02-07 Mun-Keat Looi
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India's organ transplant paradox: women donate the most and receive the least. BMJ (IF 93.6) Pub Date : 2025-02-07 Rupsa Chakraborty
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CORRECTION: Ozempic v Mounjaro: what is the difference between semaglutide and tirzepatide? BMJ (IF 93.6) Pub Date : 2025-02-07
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Academic medicine: integrating community insights and equity. BMJ (IF 93.6) Pub Date : 2025-02-07 Shahzad K Jamil,Mark I Johnson
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