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Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy Cell Stem Cell (IF 19.8) Pub Date : 2025-02-11 Tianping Peng, Xiujian Ma, Wei Hua, Changwen Wang, Youjun Chu, Meng Sun, Valentina Fermi, Stefan Hamelmann, Katharina Lindner, Chunxuan Shao, Julia Zaman, Weili Tian, Yue Zhuo, Yassin Harim, Nadja St?ffler, Linda Hammann, Qungen Xiao, Xiaoliang Jin, Rolf Warta, Catharina Lotsch, Ying Mao
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Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2 Cell (IF 45.5) Pub Date : 2025-02-11 Serena Lucotti, Yusuke Ogitani, Candia M. Kenific, Jacob Geri, Young Hun Kim, Jinghua Gu, Uthra Balaji, Linda Bojmar, Lee Shaashua, Yi Song, Michele Cioffi, Pernille Lauritzen, Oveen M. Joseph, Tetsuhiko Asao, Paul M. Grandgenett, Michael A. Hollingsworth, Christopher Peralta, Alexandra E. Pagano, Henrik Molina, Harry B. Lengel, David Lyden
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Distinct mismatch-repair complex genes set neuronal CAG-repeat expansion rate to drive selective pathogenesis in HD mice Cell (IF 45.5) Pub Date : 2025-02-11 Nan Wang, Shasha Zhang, Peter Langfelder, Lalini Ramanathan, Fuying Gao, Mary Plascencia, Raymond Vaca, Xiaofeng Gu, Linna Deng, Leonardo E. Dionisio, Ha Vu, Emily Maciejewski, Jason Ernst, Brinda C. Prasad, Thomas F. Vogt, Steve Horvath, Jeffrey S. Aaronson, Jim Rosinski, X. William Yang
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Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution Cell (IF 45.5) Pub Date : 2025-02-11 Alan Y. Hsu, Qingxiang Huang, Xiong Pi, Jianing Fu, Krishnan Raghunathan, Laxman Ghimire, Arumugam Balasubramanian, Xuemei Xie, Hongbo Yu, Fabien Loison, Viraga Haridas, Jiali Zha, Fei Liu, Shin-young Park, Kamal Bagale, Qian Ren, Yuping Fan, Yi Zheng, Jose A. Cancelas, Li Chai, Hongbo R. Luo
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Ribophagy relies on Rpl12 Nat. Cell Biol. (IF 17.3) Pub Date : 2025-02-11 Katarzyna Tutak, Katrin Karbstein
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Rpl12 is a conserved ribophagy receptor Nat. Cell Biol. (IF 17.3) Pub Date : 2025-02-11 Yuting Chen, Jiaxin Hu, Pengwei Zhao, Jie Fang, Yingqi Kuang, Zhaojie Liu, Shuling Dong, Weijing Yao, Yuanyuan Ding, Xinhui Wang, Yibin Pan, Jianbin Wu, Jingwei Zhao, Jing Yang, Zhenzhong Xu, Xiaodi Liu, Yi Zhang, Choufei Wu, Liqin Zhang, Mingzhu Fan, Shan Feng, Zhi Hong, Zhangming Yan, Hongguang Xia, Kaiyue Tang, Bing Yang, Wei Liu, Qiming Sun, Kunrong Mei, Wei Zou, Yunpeng Huang, Du Feng, Cong Yi
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Gains in early-onset dementia with progranulin open new paths for drug discovery Nat. Biotechnol. (IF 33.1) Pub Date : 2025-02-11
The first clinical results in patients with a genetic form of frontotemporal dementia (FTD) show that enhancing progranulin in the brain may halt disease progression. If successful, this potentially disease-modifying approach may uncover new avenues for treating other neurodegenerative diseases.
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Precise RNA targeting with CRISPR–Cas13d Nat. Biotechnol. (IF 33.1) Pub Date : 2025-02-11 Sydney K. Hart, Simon Müller, Hans-Hermann Wessels, Alejandro Méndez-Mancilla, Gediminas Drabavicius, Olivia Choi, Neville E. Sanjana
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Outdated rules on expenses prevent academics from travelling more sustainably Nature (IF 50.5) Pub Date : 2025-02-11
Letter to the Editor
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Amazing Australopithecus — excitement from 1925 about a ‘man ape’ fossil find Nature (IF 50.5) Pub Date : 2025-02-11
Snippets from Nature’s past.
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Close the biodiversity funding gap by teaching conservation to financial professionals Nature (IF 50.5) Pub Date : 2025-02-11
Letter to the Editor
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‘Aqua tweezers’ manipulate particles with water waves Nature (IF 50.5) Pub Date : 2025-02-11
Researchers create precise 3D patterns with water-waves.
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Nature markets are nothing new — they are widespread, regulated and instructive Nature (IF 50.5) Pub Date : 2025-02-11
Letter to the Editor
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Federico Mayor Zaragoza obituary: former UNESCO chief who championed neonatal screening Nature (IF 50.5) Pub Date : 2025-02-11
The biochemist introduced the first heel-prick tests for newborn babies in Spain, protecting infants from life-changing metabolic conditions.
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Your brain is full of microplastics: are they harming you? Nature (IF 50.5) Pub Date : 2025-02-11
Plastics have infiltrated every recess of the planet, including your lungs, kidneys and other sensitive organs. Scientists are scrambling to understand their effects on health.
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‘Male-dominated campuses belong to the past’: the University of Tokyo tackles the gender gap Nature (IF 50.5) Pub Date : 2025-02-11
A range of initiatives, from financial-support schemes to awareness campaigns, is already changing the university’s environment.
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Japan can be a science heavyweight once more — if it rethinks funding Nature (IF 50.5) Pub Date : 2025-02-11 Keisuke Goda, Tatsushi Igaki, Bernd Kuhn, Noboru Mizushima, Takeharu Nagai, Atsuhiro Nakagawa, Noriko Osumi, Amy Q. Shen, Masahiro Sonoshita, Masashi Yanagisawa
The nation must lose its tight focus on individual disciplines if it is to keep pace with the evolving requirements of scientific enquiry.
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Earth’s mysterious inner core really is changing shape Nature (IF 50.5) Pub Date : 2025-02-10
Earthquakes ringing through the planet illuminate how its heart is transforming.
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The Greenland Ice Sheet is fracturing faster than expected Nature (IF 50.5) Pub Date : 2025-02-10 Holly Smith
Cracks in Greenland's glaciers deepened by climate change.
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A man was destined for early Alzheimer’s — these genes might explain his escape Nature (IF 50.5) Pub Date : 2025-02-10
Scientists identify nine genetic variants that could have helped a man to avoid dementia for at least two decades longer than expected.
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Daily briefing: How did childhood evolve? Nature (IF 50.5) Pub Date : 2025-02-10
An AI system is crushing it at the International Mathematical Olympiad. Plus, what an iconic fossil teaches us about the evolution of childhood.
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‘Devastating’ cuts to NIH grants by Trump’s team put on hold by US judge Nature (IF 50.5) Pub Date : 2025-02-10
The ruling temporarily halts a policy slashing research overhead costs in 22 states, which filed a lawsuit against the biomedical agency.
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Author Correction: A map of the rubisco biochemical landscape Nature (IF 50.5) Pub Date : 2025-02-10 Noam Prywes, Naiya R. Phillips, Luke M. Oltrogge, Sebastian Lindner, Leah J. Taylor-Kearney, Yi-Chin Candace Tsai, Benoit de Pins, Aidan E. Cowan, Hana A. Chang, Renée Z. Wang, Laina N. Hall, Daniel Bellieny-Rabelo, Hunter M. Nisonoff, Rachel F. Weissman, Avi I. Flamholz, David Ding, Abhishek Y. Bhatt, Oliver Mueller-Cajar, Patrick M. Shih, Ron Milo, David F. Savage
Correction to: Nature https://doi.org/10.1038/s41586-024-08455-0 Published online 22 January 2025
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The African Animal Breeding Network as a pathway towards genetic improvement of livestock Nat. Genet. (IF 31.7) Pub Date : 2025-02-10 Appolinaire Djikeng, Victor E. Olori, Isidore Houaga, Samuel E. Aggrey, Okeyo Mwai, Eveline M. Ibeagha-Awemu, Raphael Mrode, Mizeck G. G. Chagunda, Christian K. Tiambo, Romdhane Rekaya, Oyenkanmi Nash, Zabron Nziku, Oluyinka Opoola, Mapholi Ntanganedzeni, Chinyere Ekine-Dzivenu, Alexander Kahi, Tobias Okeno, John M. Hickey, Negussie Enyew, Edward J. O. Rege
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Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer Nat. Genet. (IF 31.7) Pub Date : 2025-02-10 Slim Mzoughi, Megan Schwarz, Xuedi Wang, Deniz Demircioglu, Gulay Ulukaya, Kevin Mohammed, Habiba Zorgati, Denis Torre, Lewis E. Tomalin, Federico Di Tullio, Carlos Company, Yuliia Dramaretska, Marc Leushacke, Bruno Giotti, Tamsin RM Lannagan, Daniel Lozano-Ojalvo, Panagiotis Karras, Peter B. Vermeulen, Dan Hasson, Robert Sebra, Alexander M. Tsankov, Owen J. Sansom, Jean-Christophe Marine, Nick Barker
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Prioritizing effector genes at trait-associated loci using multimodal evidence Nat. Genet. (IF 31.7) Pub Date : 2025-02-10 Marijn Schipper, Christiaan A. de Leeuw, Bernardo A. P. C. Maciel, Douglas P. Wightman, Nikki Hubers, Dorret I. Boomsma, Michael C. O’Donovan, Danielle Posthuma
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Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups Nat. Genet. (IF 31.7) Pub Date : 2025-02-10 Thomas J. Hoffmann, Rebecca E. Graff, Ravi K. Madduri, Alex A. Rodriguez, Clinton L. Cario, Karen Feng, Yu Jiang, Anqi Wang, Robert J. Klein, Brandon L. Pierce, Scott Eggener, Lin Tong, William Blot, Jirong Long, Louisa B. Goss, Burcu F. Darst, Timothy Rebbeck, Joseph Lachance, Caroline Andrews, Akindele O. Adebiyi, Ben Adusei, Oseremen I. Aisuodionoe-Shadrach, Pedro W. Fernandez, Mohamed Jalloh, Rohini
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I grow medicinal mushrooms in my renewable-energy laboratory Nature (IF 50.5) Pub Date : 2025-02-10
When Ho Thi Thanh Van isn’t creating materials for fuel cells, she is cultivating traditional medicines.
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Breaking language barriers: ‘Not being fluent in English is often viewed as being an inferior scientist’ Nature (IF 50.5) Pub Date : 2025-02-10
Biologist Tatsuya Amano works to make science a fairer place for non-fluent speakers.
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How to end outrage and detoxify politics: share stories, not statistics Nature (IF 50.5) Pub Date : 2025-02-10
A book on human morality claims that although liberals and conservatives prioritize different victims, mutual understanding is still possible.
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How and why my company pivoted from energy to agritechnology Nature (IF 50.5) Pub Date : 2025-02-10
Lambda Agri chief executive Monica Saavedra describes funding strategies and the circumstances leading to the company changing strategic direction.
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Daily briefing: People in dense crowds move in swirls Nature (IF 50.5) Pub Date : 2025-02-07
People begin to move in vortices in densely packed crowds. Plus, the scientists who kept research alive in Gaza during the Israel–Hamas conflict.
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Daily briefing: How mantis shrimps survive landing the world’s fastest punch Nature (IF 50.5) Pub Date : 2025-02-07
What’s behind the mantis shrimp’s powerful punch? Plus, six ways to cultivate allyship for a diverse, equitable and inclusive academia.
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Giant RNA genomes: Roles of host, translation elongation, genome architecture, and proteome in nidoviruses Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Benjamin W. Neuman, Alexandria Smart, Orian Gilmer, Redmond P. Smyth, Josef Vaas, Nicolai B?ker, Dmitry V. Samborskiy, Ralf Bartenschlager, Stefan Seitz, Alexander E. Gorbalenya, Neva Caliskan, Chris Lauber
Positive-strand RNA viruses of the order Nidovirales have the largest known RNA genomes of vertebrate and invertebrate viruses with 36.7 and 41.1 kb, respectively. The acquisition of a proofreading exoribonuclease (ExoN) by an ancestral nidovirus enabled crossing of the 20 kb barrier. Other factors constraining genome size variations in nidoviruses remain poorly defined. We assemble 76 genome sequences
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Ancient origin and high diversity of zymocin-like killer toxins in the budding yeast subphylum Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Padraic G. Heneghan, Letal I. Salzberg, Eoin ? Cinnéide, Jan A. Dewald, Christina E. Weinberg, Kenneth H. Wolfe
Zymocin is a well-characterized killer toxin secreted by some strains of the yeast Kluyveromyces lactis . It acts by cleaving a specific tRNA in sensitive recipient cells. Zymocin is encoded by a killer plasmid or virus-like element (VLE), which is a linear DNA molecule located in the cytosol. We hypothesized that a tRNA-cleaving toxin similar to zymocin may have caused the three parallel changes to
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Clinical evaluation of patterned dried plasma spot cards to support quantification of HIV viral load and reflexive genotyping Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Giorgio Gianini Morbioli, Keith R. Baillargeon, Monalisa N. Kalimashe, Vibha Kana, Hloniphile Zwane, Cheri van der Walt, Allison J. Tierney, Andrea C. Mora, Mark Goosen, Rivashni Jagaroo, Jessica C. Brooks, Ewaldé Cutler, Gillian Hunt, Michael R. Jordan, Alice Tang, Charles R. Mace
Quantifying viral load, a key indicator required to achieve control and elimination of the HIV epidemic, requires cell-free plasma or serum to ensure measurements are not biased by proviral DNA contained in infected CD4 T lymphocytes. Plasma separation cards (PSC) collect and preserve a dried specimen, which makes them practical solutions for decentralized sample collection and transport in limited-resource
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Reenacting a mouse genetic evolutionary arms race in yeast reveals that SLXL1/SLX compete with SLY1/2 for binding to Spindlins Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Martin F. Arlt, Alyssa N. Kruger, Callie M. Swanepoel, Jacob L. Mueller
The house mouse X and Y chromosomes have recently acquired multicopy, rapidly evolving gene families representing an evolutionary arms race. This arms race between proteins encoded by X-linked Slxl1 / Slx and Y-linked Sly gene families can distort offspring sex ratio, but how these proteins compete remains unknown. Here, we report how Slxl1 / Slx and Sly encoded proteins compete in a protein family–specific
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Debiasing job ads by replacing masculine language increases gender diversity of applicant pools Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Joyce C. He, Sonia K. Kang
Job advertisements for jobs in male-dominated fields tend to contain more masculine language, and a commonly proposed intervention to increase gender diversity in applicant pools is to remove this language. In our research, we offer predictions about the broader impact of such interventions on individuals who may not “fit” with traditional masculine identity. Across four multimethod studies ( N = 37
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Inhibition of GABARAP or GABARAPL1 prevents aminoglycoside- induced hearing loss Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Jinan Li, Seung-Il Oh, Chang Liu, Bo Zhao
Aminoglycosides (AGs) are highly potent, broad-spectrum antibiotics frequently used as first-line treatments for multiple life-threatening infections. Despite their severe ototoxicity, causing irreversible hearing loss in millions of people annually, no preventive therapy has been approved. We previously reported that GABARAP and several other central autophagy proteins are essential for AG-induced
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Dynamic changes in histone lysine lactylation during meiosis prophase I in mouse spermatogenesis Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Xiaoyu Zhang, Yan Liu, Ning Wang
Male germ cells, which are responsible for producing millions of genetically diverse sperm through meiosis in the testis, rely on lactate as their central energy metabolite. Recent study has revealed that lactate induces epigenetic modification in cells through histone lysine lactylation. Here, we report dynamic histone lactylation at histone H4-lysine 5 (K5), -K8, and -K12 during meiosis prophase
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Seesaw protein: Design of a protein that adopts interconvertible alternative functional conformations and its dynamics Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Toma Ikeda, Tatsuya Nojima, Souma Yamamoto, Ryusei Yamada, Tatsuya Niwa, Hiroki Konno, Hideki Taguchi
According to classical Anfinsen’s dogma, a protein folds into a single unique conformation with minimal Gibbs energy under physiological conditions. However, certain proteins may fold into two or more conformations from single amino acid sequences. Here, we designed a protein that adopts interconvertible alternative functional conformations, termed “seesaw” protein (SSP). An SSP was engineered by fusing
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Resolving the dynamic correlated disorder in KTa 1? x Nb x O 3 Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Xing He, Mayanak K. Gupta, Douglas L. Abernathy, Garrett E. Granroth, Feng Ye, Barry L. Winn, Lynn Boatner, Olivier Delaire
Understanding the complex temporal and spatial correlations of ions in disordered perovskite oxides is critical to rationalize their functional properties. Here, we provide insights into the longstanding controversy regarding the off-centering of transition metal (TM) ions in the archetypal ferroelectric alloy KTa 1 ? x Nb x O 3 (KTN). By mapping the full energy ( E ) and wavevector ( Q ) dependence
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Ethylene response factor SlERF.D6 promotes ripening in part through transcription factors SlDEAR2 and SlTCP12 Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Yao Chen, Xin Wang, Vincent Colantonio, Zhuo Gao, Yangang Pei, Tara Fish, Jie Ye, Lance Courtney, Theodore W. Thannhauser, Zhibiao Ye, Yongsheng Liu, Zhangjun Fei, Mingchun Liu, James J. Giovannoni
Ripening is crucial for the development of fleshy fruits that release their seeds following consumption by frugivores and are important contributors to human health and nutritional security. Many genetic ripening regulators have been identified, especially in the model system tomato, yet more remain to be discovered and integrated into comprehensive regulatory models. Most tomato ripening genes have
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Machine learning–enhanced surface-enhanced spectroscopic detection of polycyclic aromatic hydrocarbons in the human placenta Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Oara Neumann, Yilong Ju, Andres B. Sanchez-Alvarado, Guodong Zhou, Weiwu Jiang, Bhagavatula Moorthy, Melissa A. Suter, Ankit Patel, Peter Nordlander, Naomi J. Halas
The detection and identification of polycyclic aromatic hydrocarbons (PAHs) and their derivatives, polycyclic aromatic compounds (PACs), are essential for environmental and health monitoring, for assessing toxicological exposure and their associated health risks. PAHs/PACs are the most dangerous chemicals found in tobacco smoke, and cigarette use during pregnancy can convey these molecules to the developing
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Wholesale flat subduction of the Indian slab and northward mantle convective flow: Plateau growth and driving force of the India–Asia collision Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Jincheng Ma, Xiaodong Song, Hans-Peter Bunge, Andreas Fichtner, You Tian
The tectonic evolution of the Tibetan Plateau has been influenced by continental collision and postcollisional convergence of Indian and Eurasian plates, both of which have undoubtedly imposed their imprints on the lithosphere and upper-mantle structures beneath the collision zone. However, the mode by which the Indian Plate has subducted beneath Tibet, and its driving forces, have been highly uncertain
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Early colonization of the deep-sea bottom—The protracted build-up of an ecosystem Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Luis A. Buatois, M. Gabriela Mángano, Maximiliano Paz, Nicholas J. Minter, Kai Zhou
Our understanding of the patterns and processes behind the evolution of deep-marine ecosystems is limited because the body-fossil record of the deep sea is poor. However, that gap in knowledge may be filled as deposits are host to diverse and abundant trace fossils that record the activities of benthic deep-marine organisms. Here, we built a global dataset of trace-fossil occurrences from a comprehensive
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Identification of FSH-regulated and estrous stage–specific transcriptional networks in mouse ovaries Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Kathryn Walters, Amber Baldwin, Zhenghui Liu, Mark Larsen, Neelanjan Mukherjee, T. Rajendra Kumar
Follicle-stimulating hormone (FSH) acts by binding to FSHRs expressed on ovarian granulosa cells and produces estradiol. FSH is essential for female fertility because mice lacking FSH ( Fshb KO ) are anestrous and infertile. Although several in vitro cell culture and ex vivo approaches combined with pharmacological hormone treatment were used to identify FSH-regulated genes, how FSH orchestrates ovarian
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Thermoelastic twisting–assisted crystal jumping based on a self-healing molecular crystal Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Zhihua Wang, Puxin Cheng, Wenqing Han, Rongchao Shi, Jian Xu, Yongshen Zheng, Jialiang Xu, Xian-He Bu
Adaptive crystals have attracted significant attention from solid-state chemists and crystal engineers for their promising applications in memories, capacitors, sensors, and actuators. Among them, thermosalient crystals are particularly favored thanks to their efficient energy conversions and rapid responses. However, the mechanisms for the mechanical responses of thermosalient crystals remain largely
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Bacterial species with different nanocolony morphologies have distinct flow-dependent colonization behaviors Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Kelsey M. Hallinen, Steven P. Bodine, Howard A. Stone, Tom W. Muir, Ned S. Wingreen, Zemer Gitai
Fluid flows are dominant features of many bacterial environments, and flow can often impact bacterial behaviors in unexpected ways. For example, the most common type of cardiovascular infection is heart valve colonization by gram-positive bacteria like Staphylococcus aureus and Enterococcus faecalis (endocarditis). This behavior is counterintuitive because heart valves experience high shear rates that
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Astrocytic EphA4 signaling is important for the elimination of excitatory synapses in Alzheimer’s disease Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Xin Yang, Ye Wang, Yi Qiao, Jingwen Lin, Jackie K. Y. Lau, Wing-Yu Fu, Amy K. Y. Fu, Nancy Y. Ip
Cell surface receptors, including erythropoietin-producing hepatocellular A4 (EphA4), are important in regulating hippocampal synapse loss, which is the key driver of memory decline in Alzheimer’s disease (AD). However, the cell-specific roles and mechanisms of EphA4 are unclear. Here, we show that EphA4 expression is elevated in hippocampal CA1 astrocytes in AD conditions. Specific knockout of astrocytic
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Double assurance in the induction of axial development by egg dorsal determinants in Xenopus embryos Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Yagmur Azbazdar, Edward M. De Robertis
We recently reported that microinjection of Xenopus nodal-related ( xnr ) mRNAs into β-catenin-depleted Xenopus embryos rescued a complete dorsal axis. Xnrs mediate the signal of the Nieuwkoop center that induces the Spemann–Mangold organizer in the overlying mesoderm, a process inhibited by the Nodal antagonist Cerberus-short (CerS). However, β-catenin also induces a second signaling center in the
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Maple samaras recover autorotation following raindrop collisions Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Breanna M. Schaeffer, Tadd T. Truscott, Andrew K. Dickerson
Samaras are known for their elegant and robust autorotation, a resilience that persists in the adverse conditions imposed by high-speed raindrops. Like flying insects, samaras descending from tall trees are likely to be struck by raindrops in an intense storm. In this study, we detail the collision dynamics for impact regions across the samara body and the drop-shedding mechanisms that samaras exhibit
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Oncofetal reprogramming induces phenotypic heterogeneity in colorectal cancer Nat. Genet. (IF 31.7) Pub Date : 2025-02-07
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“We are a target”: scientific society under pressure after Trump DEI crackdown Nature (IF 50.5) Pub Date : 2025-02-07
The American Society for Microbiology deleted terms such as equity from its website, sparking protests from members.
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Have Trump’s anti-DEI orders hit private funders? HHMI halts inclusive science programme Nature (IF 50.5) Pub Date : 2025-02-07
The Howard Hughes Medical Institute, a huge funder of biomedical research, has cut a $60-million initiative to boost diversity in science education.
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DeepMind AI crushes tough maths problems on par with top human solvers Nature (IF 50.5) Pub Date : 2025-02-07
The company’s AlphaGeometry2 reaches the level of gold-medal students in the International Mathematical Olympiad.
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Publisher Correction: Functional innovation through new genes as a general evolutionary process Nat. Genet. (IF 31.7) Pub Date : 2025-02-07 Shengqian Xia, Jianhai Chen, Deanna Arsala, J. J. Emerson, Manyuan Long
Correction to: Nature Genetics https://doi.org/10.1038/s41588-024-02059-0, published online 28 January 2025.
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Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses Cell (IF 45.5) Pub Date : 2025-02-07 Cheng-Bao Ma, Chen Liu, Young-Jun Park, Jingjing Tang, Jing Chen, Qing Xiong, Jimin Lee, Cameron Stewart, Daniel Asarnow, Jack Brown, M. Alejandra Tortorici, Xiao Yang, Ye-Hui Sun, Yuan-Mei Chen, Xiao Yu, Jun-Yu Si, Peng Liu, Fei Tong, Mei-Ling Huang, Jing Li, Huan Yan
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Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronaviruses Cell (IF 45.5) Pub Date : 2025-02-07 Young-Jun Park, Chen Liu, Jimin Lee, Jack T. Brown, Cheng-Bao Ma, Peng Liu, Risako Gen, Qing Xiong, Samantha K. Zepeda, Cameron Stewart, Amin Addetia, Caroline J. Craig, M. Alejandra Tortorici, Abeer N. Alshukairi, Tyler N. Starr, Huan Yan, David Veesler